Key References:
1. (quote) Lopez, D.A, Williams, R.M., Miehlke, M. Enzymes the Fountain of Life2. Shibata, H., Watanabe, S., Kumagai, S.Kobayashi, N. Intervention trial to improve nutritional status in frail elders using a digestive enzyme drug. Department of Community Health, Tokyo Metropolitan Institute of Gerontology, 35-2 Sakae-cho [Unpublished but in binder??]
3. Urano T, Ihara H, Umemura K, Suzuki Y, Oike M, Akita S, Tsukamoto Y, Suzuki I, Takada A. The profibrinolytic enzyme subtilisin NAT purified from Bacillus subtilis Cleaves and inactivates plasminogen activator inhibitor type 1. J Biol Chem. 2001 Jul 6;276(27):24690-6. Epub 2001 Apr 26.
4. Chang CT, Fan MH, Kuo FC, Sung HY. Potent fibrinolytic enzyme from a mutant of Bacillus subtilis IMR-NK1. J Agric Food Chem. 2000 Aug;48(8):3210-6.
5. Braga, P.C, Piatti, G., Grasselli, G., Casali W., Beghi G., Allegra L. The Influence of seaprose on Erythromycin penetration into bronchial mucus in brochopulmonary infections. Drugs Exptl. Clin. Res. 1992. XVIII(3) 105-111
6. Am J cardiology 8: 43, 1963
7. Lipids 32: 1147, 1997
8. Sumi H, Hamada H, Nakanishi K, Hiratani H. Enhancement of the fibrinolytic activity in plasma by oral administration of nattokinase. Acta Haematol 1990; 84:139-143.
9. Maruyama M, Sumi H. Effect of Natto Diet on Blood Pressure. JTTAS,1995.
10. Sumi H, Hamada H, Tsushima H, Mihara H, Muraki H. A novel fibrinolytic enzyme (nattokinase) in the vegetable cheese Natto; a typical and popular soybean food in the Japanese diet. Experientia 1987, Oct 15;43 (10):1110-1.
11. Sumi H, Hamada H, Mihari K, Nakanishi K, Hiratani H. Fibrinolytic effect of the Japanese traditional food "natto" (nattokinase). Thromb. Haemostas 1989. 62:549
12. Sumi H, Hamada H, Tsushima H, Mihara. A novel strong fibrinolytic enzyme (nattokinase) in the vegetable cheese "natto". 1998. Fibrinolysis, 2(sup. 1): 67
13. Maruyama M, Sumi H. Effect of natto diet on blood pressure. Basic and Clinical Aspects of Japanese Traditional Food Natto 1998: 1-3
14. Hayashi T, Takahashi C, Kikuchi Y. Effect of NKCP, a powder produced from dried culture filtrate of partially distilled Bacillus subtilis, on fluidity of blood. Hemorheology and Related Research 5(1):43-44.
15. Armstrong PB, Quigley JP. Alpha2-macroglobulin: an evolutionarily conserved arm of the innate immune system. Dev Comp Immunol. 1999 Jun-Jul;23(4-5):375-90. Review.
16. LaMarre J, Wollenberg GK, Gonias SL, Hayes MA. Cytokine binding and clearance properties of proteinase-activated alpha 2-macroglobulins. Lab Invest. 1991 Jul;65(1):3-14. Review.
17. Veremeenko KN, Semeniuta OS, Kizim AI, Lobunets KA. [Alpha 2-macroglobulin: structure, properties and physiological role] Ukr Biokhim Zh. 1983 Mar-Apr;55(2):218-33. Review. Ukrainian.
18. Bailey S.P. "Effects of Protease supplementation on muscle soreness following downhill running." Medical University of South Carolina, Charelston , SC,1999
19. Braga PC, Rampoldi C, Ornaghi A, Caminiti G, Beghi G, Allegra L. In vitro rheological assessment of mucolytic activity induced by Seaprose. Pharmacological Research 1990. 22(5):611-616.
20. Braga PC, Piatti G, Grasselli G, Casali W, Beghi G, Allegra L. The influence of Seaprose on Erythromycin penetration into bronchial mucus in bronchopulmonary infections. Brugs Exptl. Clin. Res. 1992. 18(8): 105-111
21. Moretti M, Bertoli E, Bulgarelli S, Testoni C, Guffanti EE, Marchioni CF, Braga PC. Effects of Seaprose on sputum biochemical components in chronic bronchitic patients: a double-blind study vs. placebo. 1993. Int. J. Cin. Pharm. Res. 13(5): 275-280.
22. Kida J, Kano K. Effect of oral administration of a mold protease (Onoprose SA) on the concentration of antibiotics in rat bronchial wash. 1967. 24(8)1619-1753.
23. Sasaki M, Kobayashi S, Shimada K, Iinuma R, Kiryu S, Sugiura M. Studies on the quality of commercially available semi-alkaline proteinase preparations using high-performance liquid chromatography. 1985 Feb. Chem Pharm Bull 33(2):746-52.